Pair Name | Parthenolide, Etoposide | ||
Phytochemical Name | Parthenolide (PubChem CID: 7251185 ) | ||
Anticancer drug Name | Etoposide (PubChem CID: 36462 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Parthenolide, Etoposide | |||
Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
Biological Phenomena | Induction-->Oxidative Stress | |||
Gene Regulation | Up-regulation | Expression | GSS | hsa2937 |
In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
Result | Parthenolide did not limit the cytotoxic effect of etoposide in HL-60 cells even in the case of antagonistic interaction. If parthenolide does increase GSH levels in combination with etoposide in the normal hematopoietic cells, it could protect them against the pro-oxidative effects of this anti-cancer drug. |
No. | Title | Href |
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1 | The role of oxidative stress in the cooperation of parthenolide and etoposide in HL-60 cells. Folia Med Cracov. 2020;60(4):5-17. | Click |